S18 Four hour 24 chromosome aneuploidy screening
نویسندگان
چکیده
منابع مشابه
SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH
Many studies estimate that chromosomal mosaicism within the cleavage-stage human embryo is high. However, comparison of two unique methods of aneuploidy screening of blastomeres within the same embryo has not been conducted and may indicate whether mosaicism has been overestimated due to technical inconsistency rather than the biological phenomena. The present study investigates the prevalence ...
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متن کاملDevelopment and validation of a next-generation sequencing-based protocol for 24-chromosome aneuploidy screening of embryos.
OBJECTIVE To validate a next-generation sequencing (NGS)-based method for 24-chromosome aneuploidy screening and to investigate its applicability to preimplantation genetic screening (PGS). DESIGN Retrospective blinded study. SETTING Reference laboratory. PATIENT(S) Karyotypically defined chromosomally abnormal single cells and whole-genome amplification (WGA) products, previously analyze...
متن کاملSNP microarray-based 24 chromosome aneuploidy screening demonstrates that cleavage-stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts
Although selection of chromosomally normal embryos has the potential to improve outcomes for patients undergoing IVF, the clinical impact of aneuploidy screening by fluorescence in situ hybridization (FISH) has been controversial. There are many putative explanations including sampling error due to mosaicism, negative impact of biopsy, a lack of comprehensive chromosome screening, the possibili...
متن کاملScreening for Fetal Aneuploidy
Aneuploidy is defined as having one or more extra or missing chromosomes, leading to an unbalanced chromosome number in a cell. Because each chromosome consists of hundreds of genes, the loss or gain of large chromosomal segments disrupts significant amounts of genetic material and often results in a nonviable pregnancy or offspring that may not survive after birth. In the case of a surviving n...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2012
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(12)60204-1